Developmental sensory experience balances cortical excitation and inhibition
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چکیده
منابع مشابه
Sensory Experience in Development Balances Excitation and Inhibition to Stabilize Frequency Tuning in Central Auditory Neurons.
The balance between excitation and inhibition is critical in shaping receptive field tuning properties in sensory neurons and, ultimately, in determining how sensory cues are extracted, transformed and interpreted by brain circuits. New findings suggest that developmentally-regulated, experience-dependent changes in intracortical inhibitory networks are key to defining receptive field tuning pr...
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Cortical neurons receive balanced excitatory and inhibitory membrane currents. Here, we show that such a balance can be established and maintained in an experiencedependent manner by synaptic plasticity at inhibitory synapses. The mechanism we put forward provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interac...
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Cortical compression can be a significant problem in many types of brain injuries, such as brain trauma, localized brain edema, hematoma, focal cerebral ischemia, or brain tumors. Mechanical and cellular alterations can result in global changes in excitation and inhibition on the neuronal network level even in the absence of histologically significant cell injury, often manifesting clinically a...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature09119